Skip to main content
. 2021 Dec 16;118(51):e2113373118. doi: 10.1073/pnas.2113373118

Fig. 3.

Fig. 3.

Distribution of TCGA mutations within human class A GPCRs. (A) ET score distribution of hypomutated and hypermutated positions in comparison with ET scores for all positions in class A GPCRs (Mann–Whitney test *P value < 0.05; **P value < 0.005). (B and C) Distribution of predicted mutational impact (EA scores) of the hypermutated positions in comparison with overall class A GPCR mutation EA scores from 1000 Genome Project (healthy population) in (B) nonolfactory and (C) olfactory GPCRs. The red bar indicates median of the distribution. (D) Top hypermutated positions are visualized in the β2AR protein structure (PDB ID code 2RH1). Sphere size corresponds to mutation frequency, and sphere color represents ET score. (E) Primary G protein coupling specificity of GPCRs mutated at the five selected positions (1.40, 3.50, 7.42, 7.50, and 8.51), compared to all class A GPCRs. G protein coupling data are from GPCRdb (34).