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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: J Pathol. 2021 Jun 14;254(5):589–605. doi: 10.1002/path.5704

Figure 6. Impact of endothelial removal, L-NAME treatment, and combined L-NAME/indomethacin treatment on acetylcholine-induced or sodium nitroprusside-induced vasorelaxation in normal and DMD dog femoral artery rings.

Figure 6.

(A) Acetylcholine-induced (left panels) relaxation of the femoral artery rings after mechanical removal of the endothelium (denuded, top panel), in the presence of L-NAME (middle panel), and in the presence of both L-NAME and indomethacin (bottom panel). (B) Sodium nitroprusside-induced (right panels) relaxation of the femoral artery rings after mechanical removal of the endothelium (denuded, top panel), in the presence of L-NAME (middle panel), and in the presence of both L-NAME and indomethacin (bottom panel). n = 6 for both normal and DMD. Asterisk, significantly different between normal and DMD at the same concentration of the vasodilator (acetylcholine or sodium nitroprusside).