Table 3.

Characterization of endothelin-1 (ET-1) induced vasoconstriction

	Normal	DMD
Control (normal=6, DMD=6)
Maximum tension, g	7.14 ± 0.71	5.69 ± 0.47
Maximum specific tension, g/mm2	1.70 ± 0.15	2.17 ± 0.25
Tension at the maximum ET-1 concentration, g	6.98 ± 1.05	2.89 ± 0.66*
Specific tension at the maximum ET-1 concentration, g/mm2	1.64 ± 0.18	1.09 ± 0.29
EC50, Log M	−7.98 ± 0.06	−7.85 ± 0.18
Denuded (normal=6, DMD=6)
Maximum tension, g	5.93 ± 1.18	4.15 ± 0.44α
Maximum specific tension, g/mm2	1.37 ± 0.20α	1.58 ± 0.25
Tension at the maximum ET-1 concentration, g	5.71 ± 1.45	2.37 ± 0.63
Specific tension at the maximum ET-1 concentration, g/mm2	1.31 ± 0.25	0.89 ± 0.26
EC50, Log M	−8.02 ± 0.08	−7.96 ± 0.12
L-NAME (normal=6, DMD=6)
Maximum tension, g	7.85 ± 0.80	5.83 ± 0.53
Maximum specific tension, g/mm2	1.86 ± 0.16	2.26 ± 0.36
Tension at the maximum ET-1 concentration, g	7.46 ± 1.10	2.94 ± 0.47*
Specific tension at the maximum ET-1 concentration, g/mm2	1.75 ± 0.18	1.14 ± 0.23
EC50, Log M	−7.98 ± 0.07	−7.81 ± 0.18
L-NAME + Indomethacin (normal=6, DMD=6)
Maximum tension, g	9.21 ± 1.24	7.06 ± 0.77
Maximum specific tension, g/mm2	2.17 ± 0.22	2.73 ± 0.47
Tension at the maximum ET-1 concentration, g	8.27 ± 1.76	3.42 ± 0.53*
Specific tension at the maximum ET-1 concentration, g/mm2	1.91 ± 0.29	1.25 ± 0.18
EC50, Log M	−7.97 ± 0.05	−7.87 ± 0.13

Mean ± SEM

EC50, Half-maximal effective concentration

L-NAME, Nω-Nitro-L-arginine methyl ester hydrochloride

^*Significantly different from the normal group in the same row.

^αSignificantly different from the L-NAME/Indomethacin group in the same column.