Table 6.
Values for vitamin B12 in SRM 3280 from different method development studies.
| References | Method | Value (mg/kg) | n a | Comments |
|---|---|---|---|---|
| Chen et al. (74) | LC/UV | 6.02 ± 0.05 | 15 | Part of single laboratory validation study for method precision |
| Sander et al. (46) | Microbiological assays | 4.9 ± 1.9 | 3,2 | Value assignment based on two interlaboratory studies of 3 and 2 laboratories using microbiological assays |
| Wise and Phillips (75) | LC-ICP/MS | 4.51 ± 0.38 | 10 | Results used to update certified value |
| COA updated 2011 | 4.8 ± 1.0 | Combined microbiological assay and LC-ICP/MS results for updated certified value | ||
| Matsumoto et al. (57) | LC-Visible | 4.64 ± 0.11 | 24 | |
| Raju et al. (62) | LC-ICP/MS | 4.38 ± 0.05 | 2 | |
| D'Ulivo et al. (70) | ID-LC-MS/MS | 5.41 ± 0.18 | 4 | Method used to certify two new MVM CRMs |
| Qiu et al. (68) | HPLC-DAD | 4.28 ± 0.06 | 4 | Single-laboratory validation study for vitamin B12 method |
a
n = number of replicate measurements used to determine the value.