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. 2021 Dec 3;148(23):dev200182. doi: 10.1242/dev.200182

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — SMAD4 differentially regulates gene expression in forelimb buds, but predominantly impacts the BMP pathway at E10.0 and E10.5. (A,B) Venn diagrams showing the intersection between the DEGs at E10.0 and E10.5 (A), and SMAD4 target genes at E10.0 and E10.5 (B). (C) Stacked bar plots show the percentage of DEGs functionally associated with the TGFβ (GO:0007179) and BMP (GO:0030509) pathways, respectively. (D,E) Heat maps showing the DEGs in the TGFβ (D) and BMP (E) pathways. For each gene, the log2-ratio between the expression level in each sample (E10.5 in wild-type, E10.0 and E10.5 Smad4^Δ/Δc) and the mean of the wild-type forelimb buds at E10.0 are shown. Red indicates increased expression and blue indicates reduced expression in comparison with the mean of the wild-type samples. Genes indicated in black are either TGFβ or BMP pathway specific; genes indicated in gray are shared between the two pathways. The names of some key genes in the BMP pathway are highlighted in blue. Asterisks mark the SMAD4 target genes among the DEGs.