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A model of the mechanism of regulation of AmotL2 dissociation from HB complex upon proteotoxic stress. Recruitment of poly-ubiquitylated proteins to Hsp70–Bag3 competitively inhibits association of monoubiquitin on AmotL2 with the UBA domain of LATS. This leads to dissociation of AmotL2 and disruption of interaction between LATS and YAP.
