Table 2. Univariate and multivariate analysis for overall survival of cholangiocarcinoma patients.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	P value	HR	95%CI	P value
Age (years)
≥60 vs. <60	1.351	0.781-2.601	0.311
Gender
Male vs. Female	1.216	0.674-2.360	0.587
Histological type
Adenocarcinoma vs. Non-adenocarcinoma	1.614	0.852-2.792	0.273
Differentiation grade
Poor/undifferentiated vs. Well/moderate	1.146	0.642-2.144	0.348
Vascular invasion
Positive vs. Negative	1.795	0.519-3.235	0.107
HBV infection
Positive vs. Negative	1.363	0.912-2.348	0.285
Serum CEA (ng/ml)
>5 vs. ≤5	1.476	0.721-2.783	0.445
Serum CA19-9 level (U/ml)
>37 vs. ≤37	1.292	0.839-2.433	0.182
Lymph node invasion
Positive vs. Negative	2.141	1.489-4.317	0.017*	2.284	1.163-3.895	0.009
TNM stage
III-IV vs. I-II	2.032	1.301-3.435	0.026*	1.967	0.973-3.252	0.037
circ-ZNF609 expression
Low vs. High	2.817	1.843-4.736	0.011*	2.771	1.639-5.379	0.002