Table 1. Association between YTHDC1 gene polymorphisms and neuroblastoma risk.
| Genotype |
Cases
(N = 896) |
Controls
(N = 1733) |
P a |
Crude OR
(95% CI) |
P |
Adjusted OR
(95% CI)b |
P b |
| rs2293596 T>C (HWE = 0.696) | |||||||
| TT | 580 (64.73) | 1144 (66.01) | 1.00 | 1.00 | |||
| TC | 272 (30.36) | 525 (30.29) | 1.02 (0.86–1.22) | 0.811 | 1.03 (0.86–1.23) | 0.778 | |
| CC | 44 (4.91) | 64 (3.69) | 1.36 (0.91–2.02) | 0.132 | 1.36 (0.91–2.02) | 0.130 | |
| Additive | 0.283 | 1.08 (0.94–1.25) | 0.283 | 1.08 (0.94–1.25) | 0.267 | ||
| Dominant | 316 (35.27) | 589 (33.99) | 0.513 | 1.06 (0.89–1.25) | 0.511 | 1.06 (0.90–1.26) | 0.486 |
| Recessive | 852 (95.09) | 1669 (96.31) | 0.136 | 1.35 (0.91–1.99) | 0.137 | 1.35 (0.91–2.00) | 0.137 |
| rs2293595 T>C (HWE = 0.556) | |||||||
| TT | 343 (38.28) | 601 (34.68) | 1.00 | 1.00 | |||
| TC | 411 (45.87) | 829 (47.84) | 0.87 (0.73–1.04) | 0.121 | 0.86 (0.72–1.03) | 0.102 | |
| CC | 142 (15.85) | 303 (17.48) | 0.82 (0.65–1.04) | 0.107 | 0.82 (0.65–1.04) | 0.107 | |
| Additive | 0.070 | 0.90 (0.80–1.01) | 0.070 | 0.90 (0.80–1.01) | 0.067 | ||
| Dominant | 553 (61.72) | 1132 (65.32) | 0.068 | 0.86 (0.72–1.01) | 0.068 | 0.85 (0.72–1.01) | 0.059 |
| Recessive | 754 (84.15) | 1430 (82.52) | 0.289 | 0.89 (0.72–1.11) | 0.289 | 0.89 (0.72–1.11) | 0.309 |
| rs3813832 T>C (HWE = 0.968) | |||||||
| TT | 499 (55.69) | 902 (52.05) | 1.00 | 1.00 | |||
| TC | 314 (35.04) | 697 (40.22) | 0.81 (0.69–0.97) | 0.020 | 0.81 (0.68–0.96) | 0.018 | |
| CC | 83 (9.26) | 134 (7.73) | 1.12 (0.83–1.50) | 0.452 | 1.13 (0.84–1.52) | 0.403 | |
| Additive | 0.424 | 0.95 (0.84–1.08) | 0.424 | 0.95 (0.84–1.08) | 0.446 | ||
| Dominant | 397 (44.31) | 831 (47.95) | 0.076 | 0.86 (0.73–1.02) | 0.076 | 0.86 (0.73–1.02) | 0.075 |
| Recessive | 813 (90.74) | 1599 (92.27) | 0.176 | 1.22 (0.92–1.62) | 0.177 | 1.24 (0.93–1.65) | 0.148 |
| Combined effect of protective genotypesc | |||||||
| 0–2 | 428 (47.77) | 735 (42.41) | 1.00 | 1.00 | |||
| 3 | 468 (52.23) | 998 (57.59) | 0.009 | 0.81 (0.69–0.95) | 0.008 | 0.80 (0.68–0.94) | 0.006 |
Abbreviations: OR: odds ratio; CI: confidence interval; HWE: Hardy-Weinberg equilibrium. aχ2 test for genotype distributions between neuroblastoma patients and cancer-free controls. bAdjusted for age and gender. cProtective genotypes were rs2293596 TT/TC, rs2293595 TC/CC and rs968697 TC/CC.