Figure 2.

Number of isolates per serotype in invasive pneumococcal disease patients in South Africa, 2012–2018. A) Total number of isolates; serotype 8 was the most commonly isolated (507, 12%). Black dots indicate most common serotypes in patients <15 years of age; arrowheads indicate most common serotypes in patients >15 years of age. B) Number of isolates per serotype per year of the 4 most common serotypes in the prevaccine era (1, 19A, 3, and 4) (9), the 4 most common in the vaccine era (8, 19A, 12F, and 3), and 6A and 19F. The 7-valent pneumococcal conjugate vaccine was introduced in 2009, 13-valent in 2011.