Figure 9.

Dose dependence of manganese (Mn) retention rate in newborn rats. Eight-day-old rats were intraperitoneally injected with radiotracer Mn and varying doses (0, 0.1, 1, and 10 mg/kg) of stable Mn. Graph depicts retained whole body Mn radioactivity as a percentage of initial radioactivity measured 4 h after the injection. Dose-dependent increase in Mn excretion rate is observed almost immediately after the injections for 1 mg Mn/kg and 10 mg Mn/kg injected animals. Notably, all animals show an increase in Mn excretion rate after 18 postnatal day (PND). From Ballatori et al. (68).