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Scheme i llustrating the mechanism by which deletion of neural precursor cell-expressed developmentally downregulated protein 4-2 (Nedd4-2) decreases renal outer medullary K+ (ROMK) channels in the aldosterone-sensitive distal nephron. Solid and dotted lines represent enhanced or diminished action, respectively. The large or small size of the subjects represents increased or decreased activity, respectively. ENaC, epithelial Na+ channel; L-WNK1, long with no lysine kinase 1.
