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. 2021 Dec 27;19:451. doi: 10.1186/s12951-021-01192-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The coassembly targeted to the hypoxic kidneys via integrin receptor α4β1 and αLβ2. a Western blot of the integrin α4, αL, β1 and β2 expression in Pc/C5A@EVs. b–e Western blot of the VCAM-1 (b, d) and ICAM-1 (c, e) expression in TECs or renal tissues under hypoxia. (n = 5, ^*P < 0.05 compared with normoxia group; ^**P < 0.01 compared with normoxia group) f, g Representative CLSM images of the cellular uptake of Pc/C5A@EVs after blocking of integrin β1 and β2 in hypoxic TECs or renal tissues. Scale bars = 50 µm. h, i Fluorescence imaging and quantitative analysis of IgG- or blocking antibody-treated Pc/C5@EVs in bilateral hypoxic renal injury mice. (n = 5; ^*P < 0.05 compared with the IgG group)