TABLE 3.
Female risks of SPCs after bladder, ureteral, and renal pelvic cancers and these cancer as SPCs
| Cancer A | Cancer B | Cancer A followed by cancer B | Cancer B followed by cancer A | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N | SIR | 95% CI | N | SIR | 95% CI | ||||
| Bladder | UAT | 17 | 1.20 | 0.70 | 1.93 | 12 | 0.91 | 0.47 | 1.6 |
| Stomach | 21 | 1.15 | 0.71 | 1.76 | 15 | 1.43 | 0.80 | 2.37 | |
| Small intestine | 8 | 1.86 | 0.80 | 3.69 | 4 | 1.10 | 0.29 | 2.85 | |
| CRC | 148 | 1.14 | 0.97 | 1.34 | 183 | 1.51 | 1.30 | 1.75 | |
| Liver | 27 | 1.23 | 0.81 | 1.8 | 3 | 0.37 | 0.07 | 1.09 | |
| Lung | 181 | 2.82 | 2.43 | 3.26 | 49 | 1.81 | 1.34 | 2.4 | |
| Breast | 240 | 1.11 | 0.97 | 1.26 | 382 | 1.18 | 1.07 | 1.31 | |
| Cervix | 16 | 1.57 | 0.90 | 2.56 | 43 | 3.07 | 2.22 | 4.14 | |
| Endometrium | 43 | 0.76 | 0.55 | 1.03 | 118 | 1.41 | 1.16 | 1.69 | |
| Ovary | 28 | 1.02 | 0.68 | 1.48 | 33 | 1.13 | 0.78 | 1.59 | |
| Female genital | 14 | 1.41 | 0.77 | 2.37 | 16 | 1.90 | 1.08 | 3.1 | |
| Kidney | 116 | 6.51 | 5.38 | 7.81 | 153 | 8.47 | 7.18 | 9.92 | |
| RCC | 27 | 2.26 | 1.49 | 3.29 | 30 | 2.14 | 1.44 | 3.06 | |
| Renal pelvis | 82 | 35.7 | 28.4 | 44.3 | 117 | 60.5 | 50.1 | 72.6 | |
| Ureter | 83 | 87.8 | 70.0 | 108.9 | 49 | 69.9 | 51.5 | 92.1 | |
| Melanoma | 33 | 0.97 | 0.67 | 1.37 | 44 | 1.00 | 0.73 | 1.35 | |
| Skin SCC | 95 | 1.23 | 1.00 | 1.51 | 61 | 1.10 | 0.84 | 1.42 | |
| Nervous system | 23 | 1.27 | 0.80 | 1.91 | 28 | 1.16 | 0.77 | 1.67 | |
| Thyroid | 2 | 0.36 | 0.03 | 1.33 | 10 | 1.26 | 0.60 | 2.32 | |
| Endocrine | 19 | 1.26 | 0.76 | 1.97 | 38 | 1.23 | 0.87 | 1.7 | |
| Connective tissue | 4 | 0.89 | 0.23 | 2.31 | 6 | 1.37 | 0.49 | 2.99 | |
| NHL | 31 | 1.02 | 0.69 | 1.45 | 26 | 0.94 | 0.61 | 1.37 | |
| Hodgkin lymphoma | 1 | 0.72 | 0.00 | 4.12 | 2 | 1.21 | 0.11 | 4.45 | |
| Myeloma | 8 | 0.61 | 0.26 | 1.21 | 9 | 0.95 | 0.43 | 1.81 | |
| Leukemia | 34 | 1.26 | 0.87 | 1.76 | 27 | 1.23 | 0.81 | 1.79 | |
| All | 1329 | 1.46 | 1.38 | 1.54 | 1359 | 1.47 | 1.39 | 1.55 | |
| Ureter | CRC | 7 | 2.22 | 0.88 | 4.60 | 9 | 2.13 | 0.97 | 4.06 |
| Lung | 6 | 4.10 | 1.48 | 8.99 | 2 | 1.98 | 0.19 | 7.29 | |
| Breast | 12 | 2.33 | 1.20 | 4.09 | 17 | 1.50 | 0.87 | 2.4 | |
| Cervix | 0 | — | — | — | 3 | 6.46 | 1.22 | 19.1 | |
| Endometrium | 3 | 2.23 | 0.42 | 6.61 | 15 | 4.85 | 2.71 | 8.03 | |
| Female genital | 1 | 4.04 | 0 | 23.17 | 2 | 6.95 | 0.66 | 25.6 | |
| Kidney | 8 | 18.5 | 7.89 | 36.57 | 15 | 22.5 | 12.6 | 37.2 | |
| RCC | 1 | 3.48 | 0.00 | 20.0 | 1 | 1.94 | 0 | 11.1 | |
| Renal pelvis | 6 | 197.8 | 38.8 | 236.2 | 13 | 191.5 | 101.5 | 328.3 | |
| Bladder | 49 | 69.9 | 51.5 | 92.1 | 83 | 87.8 | 70.0 | 108.9 | |
| All | 94 | 3.88 | 3.13 | 4.75 | 159 | 4.74 | 4.03 | 5.54 | |
| Renal pelvis | CRC | 20 | 2.26 | 1.38 | 3.49 | 9 | 0.88 | 0.4 | 1.68 |
| Lung | 5 | 1.14 | 0.36 | 2.68 | 7 | 2.72 | 1.08 | 5.64 | |
| Breast | 13 | 0.89 | 0.47 | 1.52 | 30 | 1.06 | 0.72 | 1.52 | |
| Cervix | 0 | — | — | — | 2 | 1.66 | 0.16 | 6.10 | |
| Endometrium | 4 | 1.02 | 0.27 | 2.64 | 14 | 1.88 | 1.02 | 3.16 | |
| Female genital | 2 | 0.52 | 0 | 2.95 | 0 | — | — | — | |
| RCC | 1 | 1.17 | 0 | 6.72 | 8 | 6.32 | 2.70 | 12.5 | |
| Bladder | 117 | 60.5 | 50.1 | 72.6 | 82 | 35.7 | 28.4 | 44.3 | |
| Ureter | 13 | 191.5 | 101.5 | 328.3 | 6 | 197.8 | 38.8 | 236.2 | |
| All | 205 | 3.08 | 2.68 | 3.53 | 194 | 2.35 | 2.03 | 2.70 | |
Note: Bold values show that the 95% CI does not overlap with 1.00.
Abbreviations: CRC, colorectal cancer; N, patient number; NHL, non‐Hodgkin lymphoma; SCC squamous cell carcinoma; SIR, standardized incidence ratio; SPC, second primary cancer; UAT, upper aerodigestive tract; 95% CI, 95% confidence interval.