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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Nov 12;1868(2):166302. doi: 10.1016/j.bbadis.2021.166302

Figure 3. Administration of anti-BST2 antibody efficiently depletes pDCs and reduces expression of type I IFNs, type I IFN-responsive genes and SS-promoting cytokines in SMGs.

Figure 3.

Anti-BST2 or isotype rat IgG was i.p. administered into 9-week-old female NOD mice on day 0 and day 2. The analyses were performed 24 hours after the last injection. (A) Percentages of pDCs (defined as CD11b−CD11cmidB220+Siglec-H+BST2+) among total SMG cells, SMG-draining lymph node, and spleen cells based on flow cytometric analysis. (B) Real-time PCR analysis of the mRNA levels of type I IFNs, type I IFN-responsive genes and SS-promoting cytokines in the SMGs. The results are presented relative to that of β-actin. All data are representative or the average of analyses of 3 mice for each group.