Table 2.

Summary of grade 3 or higher treatment-emergent adverse events according to CTCAE version 5.0

AEs regardless of attribution	Grade 3	Grade 4
Acute kidney injury	—	1 (5)
Alanine aminotransferase increased	3 (14)	—
Anorexia	1 (5)	—
Aspartate aminotransferase increased	2 (9)	—
Bone pain	1 (5)	—
Depression	1 (5)	—
Diarrhea	3 (14)	—
Disease progression	2 (9)	—
Esophageal pain	1 (5)	—
Fatigue	1 (5)	—
Febrile neutropenia	2 (9)	—
Hematuria	1 (5)	—
Hyperglycemia	1 (5)	—
Mucositis oral	2 (9)	—
Neutrophil count decreased	2 (9)	4 (18)
Platelet count decreased	6 (27)	3 (14)
Pleural effusion	1 (5)	—
Rash maculo-papular	4 (18)	—
Sepsis	—	1 (5)
Vascular access complication	2 (9)	—
White blood cell decreased	1 (5)	4 (18)

Data are expressed as N (%). CTCAE, Common Toxicity Criteria for Adverse Events.