Table 2.

Impact of age, ECOG-PS, CCI, CIRS, CIRS3⁺ on toxicity-related discontinuation and PDR

	Tox-DTD, %	P	PDR, %	P
Age
<65 y vs ≥65y	11 vs 19	.003	15 vs 18	.086
ECOG-PS
0-1 vs >1	13 vs 37	<.001	16 vs 22	.020
CCI
<2 vs ≥2	8 vs 18	.002	8 vs 18	<.001
CIRS
≤6 vs >6	13 vs 24	<.001	12 vs 27	<.001
CIRS3+
No vs yes	13 vs 29	<.001	15 vs 26	<.001
Age <65 y
CIRS ≤6 vs >6	11 vs 13	.843	14 vs 18	.537
CIRS3+ no vs yes	9 vs 31	<.001	13 vs 29	.018
Age ≥65 y
CIRS ≤ 6 vs >6	11 vs 26	.020	11 vs 29	<.001
CIRS3+ no vs yes	16 vs 29	<.001	16 vs 26	.010