Table 3.
Cox proportional regression hazards model of factor on PFS, EFS, OS, Tox-DTD, and PDR
| PFS | EFS | OS | Tox-DTD | PDR | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
HR
(95% CI) |
P |
HR
(95% CI) |
P |
HR
(95% CI) |
P |
HR
(95% CI) |
P |
HR
(95% CI) |
P | |
| Age | 0.82 (0.57-1.18) |
.296 | 0.83 (0.59-1.15) |
.254 | 0.85 (0.54-1.35) |
.496 | 0.91 (0.53-1.54) |
.722 | 0.73 (0.45-1.18) |
.201 |
| ECOG-PS | 2.43 (1.72-3.42) |
<.001 | 2.63 (1.92-3.61) |
<.001 | 3.90 (2.61-5.85) |
<.001 | 3.30 (2.09-5.20) |
<.001 | 1.52 (0.91-2.55) |
.112 |
| CIRS6 | 1.48 (1.02-2.15) |
.037 | 1.44 (1.03-2.00) |
.033 | 1.01 (0.63-1.62) |
.964 | 1.33 (0.80-2.21) |
.270 | 1.12 (0.70-1.81) |
.638 |
| CIRS3+ | 0.79 (0.52-1.19) |
.261 | 1.03 (0.71-1.48) |
.894 | 0.95 (0.58-1.56) |
.844 | 1.54 (0.94-2.51) |
.084 | 1.72 (1.08-2.75) |
.024 |
| CCI | 1.10 (0.71-1.72) |
.662 | 1.19 (0.79-1.78) |
.416 | 1.37 (0.75-2.52) |
.306 | 1.53 (0.72-3.25) |
.268 | 3.88 (1.50-10.06) |
.005 |
| Neutropenia | 1.70 (1.09-2.67) |
.020 | 1.51 (1.001-2.27) |
.049 | 1.72 (1.01-2.91) |
.044 | 1.83 (1.04-3.22) |
.038 | 1.08 (0.57-2.02) |
.814 |
| CYP3A4 | 1.07 (0.66-1.76) |
.780 | 1.26 (0.82-1.94) |
.285 | 1.09 (0.59-2.03) |
.784 | 1.15 (0.59-2.25) |
.670 | 2.05 (1.24-3.41) |
.005 |
| del(17p) and/or TP53mut | 2.19 (1.57-3.04) |
<.001 | 1.78 (1.32-2.40) |
<.001 | 2.06 (1.35-3.15) |
<.001 | 1.59 (0.98-2.57) |
.059 | 0.94 (0.60-1.48) |
.800 |
| Lines of previous Tx | 1.85 (1.17-2.95) |
.009 | 1.65 (1.10-2.48) |
.015 | 2.73 (1.33-5.60) |
.006 | 1.80 (0.97-3.34) |
.064 | 1.32 (0.79-2.22) |
.289 |