Figure 2.

Structure of STAT3 protein. STAT3 consists of six major components, including CCD, DBD, LD, SH2, N-terminal, and transactivation. The N-terminal domain mediates the interaction between STAT3, promoter binding and transcription mechanisms. CCD domains promote the interaction of regulatory proteins and transcription factors. The DBD is involved in the regulation of STAT3 gene promoters. The SH2 domain forms a dimer by binding the phosphorylation of the STAT3 monomer with the Tyr705 region site, which is responsible for transcriptional activation of the target gene.