Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 18;3:301–311. doi: 10.1016/j.crstbi.2021.11.004

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 2 — The changes in the structure of the BRAF^WTand BRAF^V600Ewith and without ligands. (A) Superimposition of active BRAF^WT apo protein (grey) with BRAF^WT -ATP complex (yellow-red). (B) Superimposition of BRAF^V600E apo protein structure (grey) with that of BRAF^V600E-ATP complex (yellow-red). (C) Superimposition of active BRAF^WT -ATP complex (grey) with BRAF^WT -Ponatinib complex (yellow-red). (D) Superimposition of BRAF^V600E -ATP complex (grey) with that of BRAF^V600E-Ponatinib complex (yellow-red). (E) Superimposition of BRAF^WT protein structure (grey) with that of BRAF^WT-Ponatinib complex (yellow-red) at chain B. (F) Superimposition of BRAF^WT protein structure (grey) with that of BRAF^WT-Ponatinib complex (yellow-red) at chain C. (G) Superimposition of BRAF^V600E protein structure (grey) with that of BRAF^V600E-Ponatinib complex (yellow-red) at chain B. (H) Superimposition of BRAF^V600E protein structure (grey) with that of BRAF^V600E-Ponatinib complex (yellow-red) at chain C. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)