Fig. 4.

Interaction of CAPE, Wi-A and Wi-N at ATP-binding site of BRAF^WTprotein. Superimposition of active BRAF^WT protein (grey) with BRAF^WT-Inhibitor complexes (yellow-red) including BRAF-CAPE complex at chain B (A) and chain C (B), BRAF-Wi-A complex at chain B (C) and chain C (D) and BRAF-Wi-N complex at chain B (E) and chain C (F). Structural elements of BRAF^WT-inhibitor complexes like activation segment (shown in firebrick color), αC-helix (orange), P loop (salmon) and R-spine residues (red lines representation). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)