Table 2.

Interactions formed by inhibitors with both chain B and C of BRAF^WT protein dimer. Interactions similar to that of interactions formed by BGB283 are highlighted in bold.

BRAFWT-Inhibitor Complex	BRAFWT-BGB283 complex		BRAFWT-VEM complex		BRAFWT-CAPE complex		BRAFWT-Wi-A complex		BRAFWT-Wi-N complex		BRAFWT-Ponatinib complex
Interactions	Chain B	Chain C	Chain B	Chain C	Chain B	Chain C	Chain B	Chain C	Chain B	Chain C	Chain B	Chain C
Hydrogen Bonds	Gly534	Cys532	Ser536	Ser536	Gln530			Ser536		Thr470	Glu533
		Asn580		Asp594
Hydrophobic interactions	Ile463	Ile463	Ile463	Ile463	Ile463	Ile463	Ile463	Ile463	Ile463	Phe468	Ile463	Ile463
	Gly464	Gly464	Gly464	Phe468	Gly464	Gly464	Gly464	Gly464	Gly464	Gly469	Val471	Val471
	Gly466	Gly466	Val471	Gly469	Val471	Phe468	Val471	Phe468	Gly466	Met484	Ala481	Tyr472
	Val471	Phe468	Ala481	Val471	Ala481	Gly469	Leu514	Gly469	Val471	Leu485	Leu514	Ala481
	Ala481	Val471	Trp531	Ala481	Leu514	Val471	Cys532	Val471	Ala481	Ala497	Ile543	Leu505
	Cys532	Ala481	Cys532	Leu505	Trp531	Ala481	Gly534	Gly534	Leu514	Phe498	Ile544	Leu514
	Gly534	Trp531	Gly534	Leu514	Cys532	Leu514	Tyr538	Phe583	Trp531		Phe583	Phe516
	Tyr538	Cys532	Phe583	Ile527	Gly534	Trp531	Ile543		Cys532			Ile527
	Ile543	Gly534		Gly534	Phe583	Cys532	Phe583		Gly534			Trp531
	Phe583	Tyr538		Phe583		Gly534			Phe583			Cys532
		Ile543		Gly593		Phe583
		Phe583		Phe595		Leu584
Polar and Charged Interactions	Ser465	Gln530	Ser465	Ser467	Ser465	Ser465	Ser465	Ser535	Ser465	Thr470	Lys483	Arg462
	Ser467	Ser535	Glu533	Lys483	Thr529	Thr529	Ser535	Ser536	Ser467	Lys483	Thr529	Ser465
	Ser535	Ser536	Ser535	Thr529	Gln530	Gln530	Ser536	His539	Lys483	Gln494	Gln530	Lys473
	Ser536	His539	Ser536	Ser535	Glu533	Ser535	His539	Asn580	Thr529	Lys578	Ser535	Thr529
	His539	Asn580	His539	Ser536	Ser535	His539	His585		Gln530	Asn580	His539	Lys483
	His585			Asn580	His539	His585			Ser535			Gln530
	Asp594			Asn581	His585	Lys591			Ser536			His539
				Asp594					His539
									His585
Pi-Pi Stacking		Phe468	Trp531	Phe583							Trp531