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. 2021 Dec 15;8:799163. doi: 10.3389/fmed.2021.799163

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Copyright © 2021 Otani, Murakami, Shiraishi, Hagiyama, Satou, Matsuki, Matsumura and Ito.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemistry. (A) Most cases of α-fetoprotein-producing endometrial carcinoma were p53-aberrant on immunohistochemistry (case 5 shown). (B) Only one case in our series was p53-wildtype (case 4). (C) Some overexpressed HER2 (case 5). (D) One case (case 2) in our series showed subclonal loss of expression of MLH1 and PMS2 (not shown). Original magnification× 100 (A–C) and ×40 (D), scale bars = 200 μm (A–C) and 500 μm (D).