Table 1.

Clinicopathological characteristics of AFP-producing endometrial carcinoma.

Case	Age	Gravidity/ parity	Sx	Serum AFP (ref < 10 ng/mL)	FIGO stage	Metastasis	Surgery	Postoperative therapy	Follow-up	Gross findings	AFP+ component	Other component	Myometrial invasion	LVIc
1	63	3/3	AVB	N/A	IA	Liver, lungs, bone (post surgery)	THBSO, LND	TC	DOD 11 Mo	28-mm nodular lesion associated with endometrial polyp	Fetal gut-like	CSb	Little	Present
2	73	2/2	AVB	WNL in disease-free state	IA	None	THBSO, LND	TC; RTx for Rec	Rec 17 Mo NED 32 Mo	27-mm lobulated polypoid mass with myometrial invasion	Hepatoid, fetal gut-like	CSb	< 1/2	Present
3	76	3/3	AVB	96 ng/mL at Rec	IB	Lungs (post surgery)	THBSO, LND	TC	Rec 24 Mo AWD 24 Mo	52-mm polypoid mass with myometrial invasion	Hepatoid, non-clear glandular	–	> 1/2	Extensive
4	48	0/0	AVB	WNL in disease-free state	IVB	LN	THBSOa, LND	TC	NED 43 Mo	11-cm uterus containing necrotic material, adhering to large and small intestines	Fetal gut-like, non-clear glandular	–	Extensive	Present
5	78	2/2	AVB	1,335 ng/mL 5 Mo post surgery	IVB	LN, bone	THBSO	TC	AWD 12 Mo	8-cm uterus containing necrotic material	Fetal gut-like, non-clear glandular	–	Extensive	Extensive

AFP, α-fetoprotein; AVB, abnormal vaginal bleeding; AWD, alive with disease; CS, carcinosarcoma; FIGO, International Federation of Gynecology and Obstetrics; LN, lymph nodes; LND, pelvic and para-aortic lymphadenectomy; LVI, lymphovascular invasion; Mo, months; N/A, not available; NED, no evidence of disease; Rec, recurrence; RTx, radiation therapy; SO, salpingo-oophorectomy; Sx, presenting symptom; TC, paclitaxel and carboplatin; THBSO, total hysterectomy and bilateral salpingo-oophorectomy; WNL, within normal limits.

^aSections of large and small intestines attached to the uterus were also resected.

^bAssociated with endometrial polyp.

^cInvestigated with D2-40 and CD31 immunohistochemistry.