Table 5.
Immunohistochemical characteristics of AFP-producing endometrial carcinoma and other endometrial neoplasms in differential diagnosis.
| Tumor type | AFP | SALL4 | PAX8 | CK7 | ER/PR | HNF1β | Napsin A | p53 | Others |
|---|---|---|---|---|---|---|---|---|---|
| AFP-producing endometrial carcinoma | + | + | - | -/+ | - | + | - | Aberrant/wt | |
| Endometrioid carcinoma | - | - | + | + | + | - | - | wt | |
| Clear cell carcinoma | - | - | + | + | - | + | + | wt/aberrant | |
| Serous carcinoma | - | - | + | + | -/+ | - | - | Aberrant | |
| Yolk sac tumora | + | + | - | - | - | + | - | Variable (32) | |
| Gastric-type adenocarcinoma of uterine cervix | - | - | + | + | - | + | - | Aberrant/wt | HIK1083+, MUC6+ |
| AFP-producing adenocarcinoma of uterine cervix (45,46) | + | + | - | NK | - | NK | NK | Aberrant in 2 reported cases | |
| Metastatic adenocarcinoma | - | - | Variable | Variable | Variable | Variable | Variable | Variable |
AFP, α-fetoprotein; CK, cytokeratin; ER, estrogen receptor; NK, not known; PR, progesterone receptor; wt, wild-type.
a
There is a conceptual overlap between AFP-producing endometrial carcinoma and yolk sac tumor.