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. 2021 Dec 15;15:787518. doi: 10.3389/fnins.2021.787518

FIGURE 1.

FIGURE 1

Establishment of rat hippocampal organotypic cultures as a 3D model to study the biocompatibility of Platinum nanoparticles (PtNPs) both in normal and pathological conditions. (A) Experimental scheme for inducing the pathological state and assessing the biocompatibility of PtNPs in the organotypic hippocampal slices. After 7 days in culture, slices are treated with kainic acid (KA) for 24 h followed by a 24-h incubation period with PtNPs. (B) Representative Fluoro-jade C staining of degenerating neurons in organotypic hippocampal slices under control condition and KA 7 uM at day 8 in vitro.