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. 2021 Dec 15;15:787518. doi: 10.3389/fnins.2021.787518

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Copyright © 2021 Gulino, Santos and Pêgo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Platinum nanoparticles (PtNPs) do not further impact neuronal integrity in normal and pathological conditions after 24 h of contact. (A) Representative beta-3 tubulin immunostaining of organotypic hippocampal slices under control conditions (untreated), PtNPs, kainic acid (KA) treatment, and KA treatment + PtNPs. Bottom charts represent the quantitative analysis of beta-3 tubulin fluorescence intensity in CA3, CA1, and dentate gyrus (DG). (B) Magnified images of CA3 region showing alterations in microtubule morphology only in KA-treated slices compared to controls, regardless of PtNPs incubation. Right chart represents the quantification of the b3-tubulin immunostaining in the high magnification CA3 area for the different slices. Data are expressed as integrated density fold change from the basal value of control slices and presented as mean ± standard error of the mean (SEM) (n = 3 independent experiments; 4–6 slices analyzed per group/experiment). Tukey’s test after one–way analysis of variance (ANOVA) was used for statistical analysis.