Table 3.
Ischemic stroke and cognitive impairment in the sickle cell disease cohort.
| Characteristics |
SCD with Ischemic stroke N = 30 |
SCD without Ischemic stroke N = 273 |
P -value |
|---|---|---|---|
| Age | 41.4 (18) | 38.5 (12) | 0.28 |
| Male sex | 17 (57) | 122 (45) | 0.21 |
| Hypertension | 2 (6.7) | 32 (12) | 0.40 |
| Diabetes mellitus | 1 (3.3) | 9 (3.3) | 0.99 |
| Hyperlipidaemia | 5 (16.7) | 2 (0.7) | <0.001 |
| Smoking | 1 (3.3) | 4 (1.5) | 0.44 |
| Ischemic heart disease | 2 (6.7) | 0 | 0.01 |
| Atrial fibrillation | 0 | 2 (0.7) | 1 |
| HbSS genotype | 24 (80) | 137 (50) | 0.001 |
| HbSC genotype | 3 (10) | 104 (38) | 0.002 |
| HbS/ßplus thalassemia genotype | 2 (6.7) | 24 (8.8) | 0.69 |
| HbS/ß0 thalassemia genotype | 1 (3.3) | 8 (3) | 1 |
| Intracranial vasculopathy | 3 (10) | 7 (2.6) | 0.03 |
| Moyamoya | 2 (6.7) | 1 (0.4) | 0.001 |
| Aneurysm | 1 (3.3) | 5 (1.8) | 0.57 |
| Arteriovenous malformation and fistula | 0 | 1 (0.4) | 1 |
| Cognitive dysfunction | 4 (13) | 3 (1) | <0.001 |
Bold values stands for statistically significance.