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Death induced by MLK family members is suppressed by the JNK pathway inhibitor CEP-1347 (200 nM). pCMS.EGFP vector and DNA encoding MLK family members, Rac1 V12, Cdc42 V12, and ΔN ASK1 in pCMS.EGFP were transfected into neuronal PC12 cells. Percentages of apoptotic nuclei were determined as for Fig. 6. The values are means of three independent experiments plus SEM.
