Figure 1.

EGFR-mediated ECM remodeling during lung cancer progression. EGFR and ECM receptors, integrins, results in Akt, Erk, and Ras pathways’ activation that participate in increasing cell migration, invasion, survival, and motility and repressing cell apoptosis; (A) Normal ECM in healthy tissue; (B) Neoplastic cells with uncontrolled cell growth promote ECM remodeling during lung cancer progression; (C) Tumor migration and invasion are mediated by collagen alignment and ECM stiffness. Blue arrows point to stimulation, upright-directed red arrows point to increase effect, and dashed red arrows point to cellular effect.