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. 2021 Dec 15;11:766659. doi: 10.3389/fonc.2021.766659

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Copyright © 2021 Hassanein, Abdel-Mawgood and Ibrahim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fibulins-mediated EGFR signaling pathways and matrix metalloproteinases in lung cancer. Fibulin (FBLN) family includes many types such as FBLN1,3&5 serve as tumor-suppressor proteoglycans. FBLN1 can inhibit EGFR activation and thus suppress cell proliferation. FBLN3 can compete with EGF and IGF-1 binding to their receptors; it also can inhibit transcription of oncogenic matrix metalloproteinases (MMP2& MMP9). FBLN3/5 can inhibit MMP7 and Erk pathway activation and thus inhibit cell invasion. Blue arrows for stimulation; dashed red arrows for cellular effect, and red “T” sign for inhibition.