Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 15;12:804870. doi: 10.3389/fimmu.2021.804870

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Tang, Liu, Ma, Wei, Liu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The TLR4/P38MAPK/IL-1β-mediated apoptosis signaling pathway was activated in WPs but not in SPs. (A) The levels of various cytokines in serum and colon tissue measured by ELISA. (B) Representative transmission electron micrographs of colonic crypts from the SP and WP groups. The low magnification image (scale bar, 5 μm; ×3,000 magnification) demonstrates abundant degeneration and the presence of necrotic cells scattered at the bottom of crypts in the WP group. The higher magnification image (scale bar, 1 μm; ×10,000 magnification) shows a typical apoptosis event characterized by fragmented nuclei and leaking of the nuclear mass (arrow). (C–E) The expression of components of the TLR4/P38MAPK/IL-1β signaling pathway and caspase-related proteins in colon tissue were determined by immunoblotting. All data are presented as the means ± SEM, Student’s t-test, *P < 0.05, **P < 0.01; n = 6.