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. 2021 Dec 15;12:767333. doi: 10.3389/fphar.2021.767333

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Copyright © 2021 Gao, Yan, Zhou, Wang, Sai, Fu, Liu and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of puerarin on body weight, sucrose preference, and depression-like behavior. (A) Body weight of all rats was recorded at days 0, 7, 14, 21, 28, 35, 42, 49, 56, 63, 70, and 77. (B) Body weight at the 77^th day was statistically analyzed. (C) Water and sucrose solution consumption at the 78^th day were carried out, and the sucrose preference rate was calculated. The time resting or activity (D), rearing numbers (E), and total distance (F) traveled during the last 4 min were recorded and statistically analyzed. Values are expressed as mean ± S.E.M (n = 8). ^## p < 0.01 vs. the normal control group; ^** p < 0.01 vs. the HFD/CUMS group.