Figure 5.

Longitudinal comparison of the MCI subgroups

(A–D) The plots show longitudinal changes in cognition and clinical rating scores, observed at baseline and at the second-year follow-up. Longitudinal changes are shown for CDR-SB scores (A and B) and ADAS scores (C and D).

(E) Kaplan-Meier plots depicting disease-free survival in the MCI-AD and MCI-CN subgroups. The MCI-CN group showed significantly better disease-free survival over time (log-rank test). Shaded areas depict confidence intervals. Longitudinal changes in CDR-SB scores (F) and ADAS scores (G), displayed by the two MCI subgroups, tested with a RM-ANOVA. MCI, mild cognitive impairment; CDR-SB, clinical dementia rating sum of boxes; ADAS, Alzheimer’s disease assessment scale. RM-ANOVA, repeated-measures analysis of variance.