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. Author manuscript; available in PMC: 2023 Feb 15.
Published in final edited form as: Biol Psychiatry. 2021 Jun 29;91(4):380–388. doi: 10.1016/j.biopsych.2021.06.016

Figure 3 -. Cross-validation of lesion network mapping results across two independent datasets.

Figure 3 -

(A) Discovery: Lesion network mapping of spiritual acceptance in a neurosurgical dataset (N = 88) identified a peak association in the periaqueductal grey (PAG, uncorrected p < 0.001; z = −10). (B) Cross-validation: Functional connectivity between this PAG location and lesion locations from an independent dataset of head trauma lesions (N = 105) was associated with religiosity (white outlines showing 8 of 105 lesions). Positive functional connectivity with the PAG is shown in warm colors (intersecting lesion locations associated with non-religiosity) while negative functional connectivity with the PAG is shown in cool colors (intersecting lesion locations associated with religiosity). (C) Discovery: Lesion network mapping of religiosity in a head trauma dataset (N = 105) also identified a peak association in the PAG (uncorrected p < 0.002; z = −11). (D) Cross-validation: Functional connectivity between this PAG location and lesion locations from an independent dataset of neurosurgical lesions (N = 88) was associated with changes in spirituality (white outlines showing 8 of 105 lesions). Positive functional connectivity with the PAG is shown in warm colors (intersecting lesion locations associated with decreased spirituality) while negative functional connectivity with the PAG is shown in cool colors (intersecting lesion locations associated with increased spirituality).