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. 2021 Dec 15;9:774370. doi: 10.3389/fcell.2021.774370

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Copyright © 2021 Kong, Sun, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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lncRNA–miRNA–mRNA axis in OA. lncRNA can combine with miRNA to promote the expression of related target genes. PTEN = phosphatase and tensin homolog; FUT2 = fucosyltransferase 2; Timp2 = tissue inhibitor of metalloproteinase 2; KDM5C = lysine demethylase 5C; DNMT3A = DNA methyltransferase 3A; TLR4 = toll-like receptor 4; CCND1 = cyclin D1; KLF4 = Krüppel-like factor 4; SYVN1 = synoviolin 1; PPARGC1B = PPARG coactivator 1 beta; H3F3B = H3 histone family 3B; PGRN = progranulin; DNM3OS = dynamin 3 opposite strand; BMPR2 = bone morphogenetic protein receptor 2.