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circRNA–miRNA–mRNA axis in OA. circRNAs can combine with miRNAs to promote the expression of related target genes. (A) circRNAs that play a role in cell proliferation and apoptosis. (B) circRNAs that play a role in degradation of the extracellular matrix and apoptosis. (C) circRNAs that play a role in degradation of the extracellular matrix, cell proliferation, apoptosis, and inflammation. NAMPT = nicotinamide phosphoribosyltransferase; MMP13 = matrix metalloproteinase.
