Figure 10.

Neuroprotective mechanism of miR-148a-3p/p35/PTEN signaling as established in the present study

Aβ, amyloid-β peptides; Akt, protein kinase B; CDK5, cyclin-dependent protein kinase 5; CREB, cAMP-response element binding protein; NFTs, neurofibrillary tangles; p25, a proteolytic fragment of p35; p35, cyclin-dependent kinase 5 regulatory subunit 1; p38, p38 mitogen-activated protein kinase; PHF, paired helical filament; PTEN, phosphatase and tensin homolog deleted on chromosome 10; RNA Pol II, RNA polymerase II.