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. 2021 Nov 29;27:256–275. doi: 10.1016/j.omtn.2021.11.019

Figure 7.

Figure 7

miR-148a-3p overexpression or PTEN silencing rescues spatial cognitive behavior in AD mice

(A) Comparison of the latency of finding the platform during 5 training days in the Morris water maze test in APP/PS1 mice infused with AAVs containing miR-148a-3p mimic, PTEN siRNA, or scrambled control. (B) Swimming speed in the navigation test. (C) Increased number of platform crossings by APP/PS1 mice treated with miR-148a-3p mimic or PTEN siRNA in the probe test. (D) Increased duration within the target quadrant of miR-148a-3p mimic- or PTEN siRNA-treated APP/PS1 mice in the probe test. (E) Representative images of tracings representing the route of mice finding the platform in the probe test on days 6 and 7. Results represent means ± SEM, n = 10. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 versus WT mice. #p < 0.05, ###p < 0.001 versus APP/PS1 scrambled controls.