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. 2021 Nov 29;27:256–275. doi: 10.1016/j.omtn.2021.11.019

Figure 8.

Figure 8

miR-148a-3p overexpression or PTEN silencing ameliorated tau pathology and neurodegeneration in AD mice

(A–H) Representative images and quantitative analysis, respectively, of immunoreactivity of AT8 (A and B), Tau 1 (C and D), PHF-1 (E and F), and Tau 5 (G and H) using immunohistochemistry of the hippocampus and cerebral cortex in APP/PS1 mice treated with miR-148a-3p mimics, PTEN siRNAs, and scrambled controls. (I and J) Representative images (I) and quantitative analysis of immunoreactivity (J) of NeuN staining in the hippocampus and cerebral cortex of APP/PS1 mice treated with miR-148a-3p mimics, PTEN siRNAs, and scrambled controls. (K and L) Representative images (K) and quantitative analysis of immunoreactivity (L) of TUNEL staining of the hippocampus and cerebral cortex tissue of APP/PS1 mice treated with miR-148a-3p mimics, PTEN siRNAs, and scrambled controls. Scale bar, 50 μm. Results represent means ± SEM, n = 3. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 versus WT mice. #p < 0.05, ##p < 0.01, ###p < 0.001 versus APP/PS1 scrambled controls.