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. 2021 Dec 15;12:791059. doi: 10.3389/fphar.2021.791059

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Copyright © 2021 Lyu, Li, Yu, Chan, Fu, Li and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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YZFDF blocked overactivation and pyroptosis of microglia and alleviated inflammatory responses at 24 h after cerebral I/R in rats. (A) Representative pictures of double immunofluorescence staining of GSDMD (red) colocalized with Iba-1 (green) in cortex and hippocampus-CA1 areas, scale bar = 50 μm. (B) Quantitative analysis of double-positive staining of GSDMD⁺/Iba-1⁺ cell number, n = 3. (C) Representative Western blots for cleaved-IL-1β, IL-6, and Iba-1. (D) Quantitative analysis of cleaved-IL-1β, IL-6, and Iba-1, n = 6. ^## p < 0.01 vs. Sham group; ^** p < 0.01 vs. I/R group.