FIGURE 2.

Docking computations of 7,8-DHF, wogonin, quercetin, and apigenin. (A) The docking conformations of tested flavones binding to d5 domain (the second immunoglobulin-like domain, 250–340 amino acid residues) of extracellular domain of tropomyosin-related kinase B (TRKB) receptor. The TRKB-d5 domain (ribbon structures) is colored in beige and the wire-frame structures denote the compounds. The labeled amino acids were within 10 Å radii of examined compounds. Carbon, oxygen, hydrogen, and nitrogen atoms of compounds or side chains of surrounding amino acids are shown in light blue, red, white, and blue, respectively. The dotted orange lines indicate hydrogen bond interactions between compounds and proteins. (B) The docking scores of 7,8-DHF, wogonin, quercetin, and apigenin calculated by the GOLD program. (C) Amino acid residues 301–350 of d5 domain. The amino acids within 10 Å radii of examined compounds are colored in red; the cysteines involved in disulfide linkage are underlined.