Reagent or resource	Source	Identifier
Antibodies
IgG	Invitrogen	A28175; RRID:AB_2536161
IgA	Southern Biotech	1040-02; RRID:AB_2794370
IgM	BD PharMingen	555782; RRID:AB_396117
C3	MP Biomedicals	SKU 0855500; RRID:AB_2334931
Vangl1	Sigma	SAB4503254; RRID:AB_10748043
VANGL1	ThermoFisher	PA5-55231; RRID:AB_2649388
VANGL1	ThermoFisher	PA5-98739; RRID:AB_2813352
VANGL2	ThermoFisher	PA5-23207; RRID:AB_2540733
Biological samples
Human PBMCs	This study	N/A
Human kidney samples	This study	N/A
Chemicals, peptides, and recombinant proteins
MiScript RT Kit	QIAGEN	218160
SYBR Green	QIAGEN	204143
Tissue-Tek O.C.T.	Sakura	4583
2% osmium tetroxide	Electron Microscopy Sciences, USA	19100
Cacodylate buffer	This study	N/A
TAAB epoxy	TAAB Laboratory and Microscopy, U.K	E049
Critical commercial assays
Affymetrix 5.0 SNP Chip	Affymetrix USA	#901167
Taqman CN Assay	Applied Biosystem, USA	Hs05725015_cn
ANA ELISA	Alpha diagnostic	5210
Total serum immunoglobulin	BD Bioscience	550487
Indiko Creatinine-detect	ThermoFisher	10015638
Albumin ELISA kit	abcam	Ab108792
Deposited data
RNA sequences	This study	GEO: GSE188480
Experimental models: Organisms/strains
C57BL/6 mice	Charles River	C57BL/6
Vangl1+/−	KOMP	EPD0164_3_G07
CD79aKen	Australian phenomics facility	N/A
Lyn−/−	Australian phenomics facility	N/A
Oligonucleotides
Vangl1 exon three F’	Integrated DNA Technologies	GACACAAGTCACCCCGGAATA
Vangl1 exon three R’	Integrated DNA Technologies	TCCTCTGTCCGAGTAGAATCATT
Vangl1 exon four F’	Integrated DNA Technologies	CCGATCCTGTGGAGGGATGA
Vangl1 exon four R’	Integrated DNA Technologies	AAACACCCGTGGCATGTCA
Software and algorithms
Graphpad Rism 8.0	GraphPad Software CA, USA	N/A
FlowJo	Tristar Inc, Stanford, US	N/A
RNA sequencing annotation	M Field	10.1371/journal.pone.0143199