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. 2021 Dec 21;2(12):100471. doi: 10.1016/j.xcrm.2021.100471

Figure 2.

Figure 2

Phosphoproteomic signatures responsive to carboplatin

(A and B) Kinase activity inferred from phosphorylation of its substrates using ssGSEA at (A) 8 h and (B) 24 h of carboplatin exposure.

(C) Kinase activity inferred from phosphorylation of its substrates (red box) and phosphorylation of its activating sites (red circle). Gray circles indicate no activating phosphorylation is available. Black arrows indicate a direct phosphorylating kinase on the activating site, and dashed arrows indicate an indirect relationship.

(D) Log2 fold change of PTM-SEA phosphosite perturbation and pathway signature scores between 24 h of carboplatin exposure and mock-treated cells. The top 10 in each direction are shown. Dashed line indicates an FDR threshold of 0.05.