Figure 4.
ERCC2, ERBB2, and ERBB3 mutations in stage T1 tumors
(A) ERCC2 protein showing positions and frequency of point mutations identified.
(B) Structure of the ERCC2 protein (PDB: 5IVW) showing positions of mutated residues. Red, residues with mutations reported previously to affect function; green, novel mutations.
(C) TMB as SNVs per megabase in ERCC2 mutant and WT samples. Bars indicate mean and SD.
(D) PFS according to ERCC2 mutation status.
(E) ERBB2 protein, showing positions and frequency of point mutations.
(F) ERBB3 protein, showing positions and frequency of point mutations.
(G) TMB as SNVs per megabase in ERBB2 (left) and ERBB3 (right) mutant and WT T1 samples. Bars indicate mean and SD.
(C and G) Mann-Whitney test.
(H) PFS according to ERBB2 and/or ERBB3 mutation status.
(D and H) Log rank analysis.