Figure 6.

Immune infiltration is related to PPARG signaling in NMIBC

(A) ESTIMATE immune signature score in T1 expression subtypes.

(B) Heatmap of Z scores for 60-gene immune cell signature¹⁹ in T1 expression subtypes.

(C) 60-gene immune score (left) and PD-L1 expression (right) according to gender in T1 tumors. Mann-Whitney test.

(D) PPARG expression according to T1 expression subtype.

(E) PPARG signature score⁵⁴ according to T1 expression subtype.

(A, D, and E) Kruskal-Wallis test with Dunn’s multiple comparison correction. ∗∗∗∗p < 0.0001, ∗∗∗p < 0.001, ∗∗p < 0.01.

(A, C, D, and E) Mean, 25th and 75th percentiles, minimum and maximum values are shown.

(F) Correlation of PPARG signature and differentiation score in T1 tumors.

(G) Correlation of PPARG signature and ESTIMATE immune score in T1 tumors.

(H) Correlation of PPARG signature and ESTIMATE immune score in Ta tumors.

(I) Correlation of PPARG signature and DNA repair gene expression in all NMIBCs.

(F–I) Pearson r. See also Figure S7 and Table S9.