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. 2021 Dec 15;9:773636. doi: 10.3389/fbioe.2021.773636

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Copyright © 2021 Yang, Zhang, Liu, Chen, Deng, Zhang, Yu and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Integrins α5β1: (a) α5β1 promote osteoblastic differentiation of mesenchymal stem cells; (b) α5β1 promote osteoblast proliferation and bone formation; (c) α5β1 also activates pro-inflammatory and catabolic responses leading to cartilage matrix degradation. (B) Integrins αvβ3: (a) αvβ3 Inhibit MSCs proliferation and osteogenic differentiation; (b) αvβ3 promote bone resorption; (c) Inhibition of αvβ3 could significantly inhibit osteoarthritis (OA) inflammation and decrease OA progression.