Figure 2.

Male rats on a high-fat diet (HFD) gained more body fat and had higher fasting insulin than female rats. Male rats weighed slightly, but significantly, more than female rats at baseline before diet treatment (A). Male rats remained heavier than females after 5 wk and weighed significantly more on a high-fat diet than females (B). Male rats on the high-fat diet weighed significantly more (B) and had greater body fat (C) than male rats on the low-fat diet (LFD). Female rats had a higher percent body fat than males independent of diet, and this did not significantly change with diet (C). Although male rats ate more calories per day than females, diet fat content did not change caloric intake (D). Fasting glucose was similar in all groups (E). Fasting insulin was increased in males on a high-fat diet compared with males on a low-fat diet and females on a high-fat diet (F). Data are presented as means ± SE. *P < 0.05.