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. 2021 Oct 20;321(6):L1105–L1118. doi: 10.1152/ajplung.00202.2021

Figure 4.

Figure 4.

Rats on a high-fat diet (HFD) gained more body weight (A) and body fat (B) and had significantly higher fasting insulin (C) than rats on a low-fat diet (LFD). Metformin prevented high-fat diet induced gain in body weight (A), body fat (B), and hyperinsulinemia (C). Fasting glucose (D) and daily food intake (E) were not changed by diet or metformin. Rats that were switched from a high-fat diet to a low-fat diet (HFD 5 wk/LFD 5 wk) had significantly decreased body weight (F) and body fat (G), but similar fasting glucose (H) and fasting insulin (I) compared with rats remained on high-fat diet for 10 wk (HFD 10 wk). Each symbol represents an individual animal. Data are presented as means ± SE. *P < 0.05 is indicated by a bracket. #P < 0.05 compared with all other groups.