Figure 4.

Divergences in CA1, subiculum (Sub), presubiculum (PrS), and molecular layer (ML) subregion volumes are preferentially associated with loneliness. Shown are the subregion divergences in mode 3 of hippocampus (HC)-default network (DN) covariation. Mode 3 of the canonical correlation analysis (CCA) solution achieves the third most explanatory hippocampal-DN covariation, with a canonical correlation of rho = 0.39. A exhibits the (HC) subregion pattern (left, one canonical vector of mode 3) with paramater weights that robustly diverge between lonely and nonlonely groups in mode 3. B shows the DN subregion pattern (right, other canonical vector of mode 3) of the DN (right) that robustly diverge between lonely and nonlonely groups. The most pronounced divergences in the loneliness group are in right ML head and body, right Sub head and body, as well as right CA1 head. Thus, similar to mode 1, within the third most explanatory pattern of HC-DN covariation, loneliness is concomitant with hippocampal divergences in CA1, Sub, PrS, and ML.