Figure 6.

Loneliness is associated with subregion divergences in parasubiculum (Para) and a distributed set of bilateral default network (DN) subregions. Shown here are the subregion divergences in mode 9 of hippocampus (HC)-DN covariation. Mode 9 of the CCA solution achieves the ninth most explanatory HC-DN covariation, with a canonical correlation of rho = 0.18. A exhibits the HC subregion pattern (left, one canonical vector of mode 9) with parameter weights that robustly diverge between lonely and nonlonely groups in mode 9. B shows the DN subregion pattern (right, other canonical vector of mode 9) of the DN (right) that robustly diverged between lonely and nonlonely groups. Overall, there are divergences for lonely individuals in left Para, as well as bilateral ventromedial prefrontal cortex (vmPFC), left retrosplenial cortex (RSC), bilateral orbitofrontal cortex (OFC), and bilateral superior temporal sulcus (STS). These results emphasize the bilateral tendency of the DN divergences observed for loneliness. The results also highlight a coherent set of reward-related subregions, as most of the subregions identified are also found to have a strong volumetric relationship with the nucleus accumbens (Fig. 2).